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KMID : 0043320100330010055
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.55 ~ p.60
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Synthesis and Antitumor Screening of New 1,7-Diphenyl-3-(1,3-disubstituted- 1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones
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Mahmoud M. El-merzabani
Ahmad S. Shawali
Sherif M. Sherif
Manal A. A. Darwish
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Abstract
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A new series of 3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-1,7-diphenyl-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones 4 was prepared by reaction of the enaminone 2 with hydrazonoyl halides 3. The preliminary screening for antitumor activity of the synthesized compounds was carried out against Ehrlich Ascites Carcinoma tumor cells. The results revealed that the studied compounds 4 have low or no antitumor activity towards EAC tumor cells.
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KEYWORD
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Enaminone, Hydrazonoyl halides, Pyrazole, [1, 2, 4]Triazolo[4, 3-a]pyrimidine
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